TY - CHAP M1 - Book, Section TI - Acquired Disorders of Coagulation A1 - Leavitt, Andrew D. A1 - Price, Erika Leemann A2 - Papadakis, Maxine A. A2 - McPhee, Stephen J. A2 - Rabow, Michael W. A2 - McQuaid, Kenneth R. Y1 - 2023 N1 - T2 - Current Medical Diagnosis & Treatment 2023 AB - Patients with antiphospholipid antibodies occasionally have antibody specificity to coagulation factor II (prothrombin) that accelerates factor II clearances and can lead to severe hypoprothrombinemia and bleeding. Mixing studies may or may not reveal the presence of an inhibitor, as the antibody typically binds to a non-enzymatically active portion of the molecule leading to accelerated clearance, but characteristically the PT is prolonged and levels of factor II are low. FFP should be administered to treat bleeding. Treatment is immunosuppressive. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=1193158950 ER -