TY  - CHAP
M1  - Book, Section
TI  - Immediate Hypersensitivity
A1  - Manno, Rebecca L.
A1  - Yazdany, Jinoos
A1  - Tarrant, Teresa K.
A1  - Kwan, Mildred
A2  - Papadakis, Maxine A.
A2  - McPhee, Stephen J.
A2  - Rabow, Michael W.
A2  - McQuaid, Kenneth R.
Y1  - 2023
N1  - 
T2  - Current Medical Diagnosis & Treatment 2023
AB  - Immediate  hypersensitivity  reactions  commonly  involve  IgE  antibodies,  which  bind  to  Fc  epsilon  RI  receptors  on  mast  cells  and  basophils.  Within  minutes  of  exposure,  the  allergen  crosslinks  cell-bound  IgE  molecules,  activating  mast  cells  or  basophils  to  degranulate.  Clinical  manifestations  of  immediate  hypersensitivity  result  from  the  action  of  released  mediators  within  tissues.  Both  preformed  and  newly  generated  mediators  from  released  granules  cause  vasodilation,  visceral  smooth  muscle  contraction,  mucous  secretory  gland  stimulation,  vascular  permeability,  and  tissue  inflammation.  Arachidonic  acid  metabolites,  cytokines,  and  other  mediators  (eg,  chemoattractants)  can  induce  a  late-phase  inflammatory  response  that  appears  several  hours  later  as  a  delayed  biphasic  reaction  or  when  allergen  exposure  is  continuous  (eg,  pollen).  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1193126178
ER  -