TY - CHAP M1 - Book, Section TI - Sustained Ventricular Tachycardia A1 - H. Sauer, William A1 - Tedrow, Usha B. A2 - Loscalzo, Joseph A2 - Fauci, Anthony A2 - Kasper, Dennis A2 - Hauser, Stephen A2 - Longo, Dan A2 - Jameson, J. Larry Y1 - 2022 N1 - T2 - Harrison's Principles of Internal Medicine, 21e AB - Sustained monomorphic ventricular tachycardia (VT) is a ventricular arrhythmia with a wide QRS lasting for 30 s or requiring an intervention for termination. Each QRS complex resembles the others, indicating either a site of origin from either an automatic focus or fixed reentry circuit. In structural heart disease, the substrate is most often an area of patchy replacement fibrosis due to infarction, fibrosis, inflammation, or prior cardiac surgery that creates anatomic or functional reentry pathways. Less commonly, VT is related to reentry or automaticity in diseased conduction pathways in the Purkinje system. While scar-related reentrant VTs are associated with risk of sudden death, idiopathic VT is a more benign form of VT that occurs in structurally normal hearts and can be due to a focal region of automaticity in the myocardium or reentry involving a portion of the Purkinje system. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/25 UR - accessmedicine.mhmedical.com/content.aspx?aid=1190496983 ER -