TY - CHAP M1 - Book, Section TI - Myalgic Encephalomyelitis/Chronic Fatigue Syndrome A1 - Unger, Elizabeth R. A1 - Lin, Jin-Mann S. A1 - Bertolli, Jeanne A2 - Loscalzo, Joseph A2 - Fauci, Anthony A2 - Kasper, Dennis A2 - Hauser, Stephen A2 - Longo, Dan A2 - Jameson, J. Larry Y1 - 2022 N1 - T2 - Harrison's Principles of Internal Medicine, 21e AB - Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic complex illness with multisystem manifestations and long-term impact on functional impairment comparable to multiple sclerosis, rheumatoid arthritis, and congestive heart failure. The hallmark of ME/CFS is persistent and unexplained fatigue resulting in significant impairment in daily functioning along with worsening symptoms following physical or mental exertion that would have been tolerated before illness (post-exertional malaise). Besides intense fatigue, many patients report concomitant symptoms such as pain, cognitive dysfunction, and unrefreshing sleep. Additional symptoms can include headache, sore throat, tender lymph nodes, muscle aches, joint aches, feverishness, difficulty sleeping, psychiatric problems, allergies, and abdominal cramps. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1199144578 ER -