TY - CHAP M1 - Book, Section TI - Small Cell Carcinoma of the Lung A1 - Ross, Jeremy A. A1 - Byers, Lauren A. A1 - Gay, Carl M. A2 - Kantarjian, Hagop M. A2 - Wolff, Robert A. A2 - Rieber, Alyssa G. Y1 - 2022 N1 - T2 - The MD Anderson Manual of Medical Oncology, 4e AB - KEY CONCEPTSSmall cell lung cancer (SCLC) is an aggressive malignancy for which outcomes remain poor. The majority of patients present with metastatic disease, and few patients are cured, even among those that present with early-stage disease. There is an urgent need for more effective therapies for this disease.For patients with stage I disease, surgical resection should be considered if mediastinal staging is negative. Adjuvant chemotherapy with four cycles of etoposide–cisplatin (EP) should be considered for all patients with surgically resected SCLC and no lymph node metastases found at the time of resection.Most patients with limited-stage disease are treated with concurrent chemoradiotherapy. Although carboplatin is frequently used in patients with extensive-stage disease, EP with twice-daily radiation therapy remains the standard of care in patients without contraindications to cisplatin.Numerous clinical trials have established the effectiveness of prophylactic cranial irradiation (PCI) in decreasing the incidence of intracranial disease, although its impact on survival has been variable. All patients with limited-stage disease who respond to treatment should receive PCI. The use of PCI in patients with extensive-stage disease remains controversial.First-line chemoimmunotherapy has recently been shown to improve survival in patients with extensive-stage disease. The development and understanding of biomarkers for response to immunotherapy is progressing and may improve outcomes for some patients.Treatment options are limited for patients with recurrent disease, and clinical trials are recommended when feasible. There are no approved targeted agents for SCLC despite a plethora of trials. SN - PB - McGraw Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1190834280 ER -