TY - CHAP M1 - Book, Section TI - Urinary Tract Infections, Pyelonephritis, and Prostatitis A1 - Gupta, Kalpana A1 - Trautner, Barbara W. A2 - Loscalzo, Joseph A2 - Fauci, Anthony A2 - Kasper, Dennis A2 - Hauser, Stephen A2 - Longo, Dan A2 - Jameson, J. Larry Y1 - 2022 N1 - T2 - Harrison's Principles of Internal Medicine, 21e AB - Urinary tract infection (UTI) is a common and painful human illness that is rapidly responsive to modern antibiotic therapy, if the correct antibiotic is chosen for the particular urinary pathogen. In the preantibiotic era, UTI caused significant morbidity. Hippocrates, writing about a disease that appears to have been acute cystitis, said that the illness could last for a year before either resolving or worsening to involve the kidneys. When chemotherapeutic agents used to treat UTI were introduced in the early twentieth century, they were relatively ineffective, and persistence of infection after 3 weeks of therapy was common. Nitrofurantoin, which became available in the 1950s, was the first tolerable and effective agent for the treatment of UTI. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/11/09 UR - accessmedicine.mhmedical.com/content.aspx?aid=1201012844 ER -