TY - CHAP M1 - Book, Section TI - Drugs Used in Dementia A1 - Stringer, Janet L. Y1 - 2022 N1 - T2 - Basic Concepts in Pharmacology: What You Need to Know for Each Drug Class, 6e AB - Dementia, including Alzheimer disease, involves a number of brain systems. There is evidence for a decrease in markers of cholinergic neuron activity and for changes in brain glutamate, dopamine, norepinephrine, serotonin, and somatostatin. Eventually, cholinergic neurons die or are destroyed. Treatment has focused on increasing the amount of acetylcholine in the synapse by inhibiting the breakdown of acetylcholine. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/18 UR - accessmedicine.mhmedical.com/content.aspx?aid=1187633717 ER -