TY  - CHAP
M1  - Book, Section
TI  - Toxicity & Dose Modification of Chemotherapeutic Agents
A1  - Wang, Sunny
A1  - Dea, Tiffany O.
A2  - Papadakis, Maxine A.
A2  - McPhee, Stephen J.
A2  - Rabow, Michael W.
A2  - McQuaid, Kenneth R.
Y1  - 2022
N1  - 
T2  - Current Medical Diagnosis & Treatment 2022
AB  - Use  of  chemotherapy  to  treat  cancer  is  generally  guided  by  results  from  clinical  trials  in  individual  tumor  types.  The  complexity  of  treating  cancer  has  increased  over  the  last  decade  as  more  drugs,  including  those  with  targeted  mechanisms  of  action,  have  been  approved  by  the  US  Food  and  Drug  Administration  (FDA)  and  introduced  into  general  practice.  Drug  side  effects  and  toxicities  must  be  anticipated  and  carefully  monitored.  The  short-  and  long-term  toxicities  of  individual  drugs  are  listed  in  Tables  39–3  and  39–12.  Decisions  on  dose  modifications  for  toxicities  should  be  guided  by  the  intent  of  therapy.  In  the  palliative  setting  where  the  aim  of  therapy  is  to  improve  symptoms  and  quality  of  life,  lowering  doses  to  minimize  toxicity  is  commonly  done.  However,  when  the  goal  of  treatment  is  cure,  dosing  frequency  and  intensity  should  be  maintained  whenever  possible.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/18
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1184390185
ER  -