TY - CHAP M1 - Book, Section TI - Primary Immunodeficiency Disorders in Adults A1 - Yazdany, Jinoos A1 - Manno, Rebecca L. A2 - Papadakis, Maxine A. A2 - McPhee, Stephen J. A2 - Rabow, Michael W. A2 - McQuaid, Kenneth R. Y1 - 2022 N1 - T2 - Current Medical Diagnosis & Treatment 2022 AB - Primary immunologic deficiency diseases are estimated to affect 1 in 4000 individuals; many are genetically determined and present in childhood. Nonetheless, several important immunodeficiency disorders present in adulthood, most notably the antibody deficiency syndromes: selective IgA deficiency, common variable immunodeficiency, and specific (functional) antibody deficiency (Table 20–14). Antibody deficiency predisposes patients to recurrent infections, particularly of the respiratory tract, including refractory chronic rhinosinusitis, bronchitis, pneumonia, and bronchiectasis. Patients are most susceptible to infections with encapsulated bacteria (eg, Haemophilus influenzae type b, Streptococcus pneumoniae, Neisseriameningitides). However, any part of the innate or adaptive immune system can be defective and results in infections with different spectra of organisms. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1184193826 ER -