TY - CHAP M1 - Book, Section TI - Overview of Hemostasis A1 - Leavitt, Andrew D. A1 - Price, Erika Leemann A2 - Papadakis, Maxine A. A2 - McPhee, Stephen J. A2 - Rabow, Michael W. A2 - McQuaid, Kenneth R. Y1 - 2022 N1 - T2 - Current Medical Diagnosis & Treatment 2022 AB - Hemostasis, the physiologic process that maintains vascular integrity and minimizes bleeding in the face of injury, requires a complex and coordinated interplay of cellular elements (platelets) and humoral (clotting) factors working in concert. Platelets are exposed to collagen, fibronectin, and other molecules in the subendothelial matrix at the site of vascular injury, which leads to platelet adherence, activation, and aggregation to form an initial platelet plug, a process that can be viewed as primary hemostasis. von Willebrand factor (vWF) facilitates platelet adherence to subendothelial collagen at the site of endothelial injury, especially in high-shear areas such as arterioles. While vWF also helps cross-link platelets, soluble fibrinogen is the primary molecule that links platelets together to form the platelet plug. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=1184168409 ER -