TY - CHAP M1 - Book, Section TI - Platelet Transfusions A1 - Damon, Lloyd E. A1 - Andreadis, Charalambos Babis A2 - Papadakis, Maxine A. A2 - McPhee, Stephen J. A2 - Rabow, Michael W. A2 - McQuaid, Kenneth R. Y1 - 2022 N1 - T2 - Current Medical Diagnosis & Treatment 2022 AB - Platelet transfusions are indicated in cases of thrombocytopenia due to decreased platelet production. They are of some use in immune thrombocytopenia when active bleeding is evident, but the clearance of transfused platelets is rapid as they are exposed to the same pathophysiologic forces as the recipient’s endogenous platelets. The risk of bleeding rises when the platelet count falls to less than 80,000/mcL (80 × 109/L), and the risk of life-threatening spontaneous bleeding increases when the platelet count is less than 5000/mcL (5 × 109/L). Because of this, prophylactic platelet transfusions are often given at these very low levels, usually when less than 10,000/mcL (10 × 109/L). Platelet transfusions are also given prior to invasive procedures or surgery in thrombocytopenic patients, and the goal is often to raise the platelet count to 50,000/mcL (50 × 109/L) or more. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1184166522 ER -