TY - CHAP M1 - Book, Section TI - Pulmonary Venous Thromboembolism A1 - Fitzpatrick, Meghan E. A1 - Prendergast, Niall T. A1 - Rivera-Lebron, Belinda A2 - Papadakis, Maxine A. A2 - McPhee, Stephen J. A2 - Rabow, Michael W. A2 - McQuaid, Kenneth R. Y1 - 2022 N1 - T2 - Current Medical Diagnosis & Treatment 2022 AB - KEY CLINICAL UPDATES IN PULMONARY VENOUS THROMBOEMBOLISMDirect-acting oral anticoagulants are recommended as first-line anticoagulation for most patients.Discontinuation of anticoagulation may be considered after 3 months for patients– With major transient/reversible risk factors (such as fracture of lower limb; hip or knee surgery)– Who were hospitalized because of heart failure, atrial fibrillation, or myocardial infarction.Guidelines support systemic thrombolysis for high-risk or massive PE (hemodynamically unstable) with low risk of bleeding.Intermediate-risk or submassive PE patients have a significant decrease in incidence of hemodynamic collapse but do not have a mortality benefit with thrombolytic therapy.They do, however, have an increase in major hemorrhagic complications, including intracranial hemorrhage. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/19 UR - accessmedicine.mhmedical.com/content.aspx?aid=1186013018 ER -