TY - CHAP M1 - Book, Section TI - Approach to Management Asthma A1 - Fitzpatrick, Meghan E. A1 - Prendergast, Niall T. A1 - Rivera-Lebron, Belinda A2 - Papadakis, Maxine A. A2 - McPhee, Stephen J. A2 - Rabow, Michael W. A2 - McQuaid, Kenneth R. Y1 - 2022 N1 - T2 - Current Medical Diagnosis & Treatment 2022 AB - KEY CLINICAL UPDATES IN APPROACH TO MANAGEMENT ASTHMAThe pathophysiology of asthma is heterogeneous, but a division into T2-high and T2-low endotypes (marked by high and low levels of classic Th2 cytokines, including IL-4, IL-5, and IL-13, respectively) has been shown to be important regarding the selection of therapies.Allergic asthma falls into the T2-high endotype, as do late-onset T2-high asthma and aspirin/NSAID-associated respiratory disease.T2-low asthma phenotypes include nonallergic asthma, which tends to occur in adults and be marked by neutrophilic inflammation and variable response to standard therapies. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=1186012475 ER -