TY - CHAP M1 - Book, Section TI - DEXTROMETHORPHAN A1 - Anderson, Ilene B. A2 - Olson, Kent R. A2 - Anderson, Ilene B. A2 - Benowitz, Neal L. A2 - Blanc, Paul D. A2 - Clark, Richard F. A2 - Kearney, Thomas E. A2 - Kim-Katz, Susan Y. A2 - Wu, Alan H. B. Y1 - 2018 N1 - T2 - Poisoning & Drug Overdose, 7e AB - Dextromethorphan is a common antitussive agent found in many over-the-counter (OTC) cough and cold preparations. Dextromethorphan is often found in combination products containing antihistamines, decongestants, ethanol, or acetaminophen. Common combination products containing dextromethorphan include Coricidin HBP Cough & Cold Tablets, Robitussin DM, and NyQuil Nighttime Cold Medicine. Dextromethorphan is well tolerated at therapeutic doses, and serious toxicity rarely occurs, even with moderate-to-high doses. However, major toxicity and death have been reported, caused either by dextromethorphan as a sole agent or more commonly by coingestants, drug–drug interactions, or genetic polymorphism. Intentional abuse, especially among adolescents and young adults, has been a continuing problem owing to the hallucinogenic potential at high doses. Common slang terms include "triple C," "CCC," "skittles," "robo," "DXM," and "dex." "Crystal Dex" and "DXemon Juice" refer to dextromethorphan extracted from the other ingredients in OTC cold medications using simple home acid–base extraction techniques. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1179991253 ER -