TY  - CHAP
M1  - Book, Section
TI  - Primary Sjögren Syndrome
A1  - Ramos-Casals, Manuel
A1  - Brito-Zerón, Pilar
A1  - Sisó-Almirall, Antoni
A2  - Stone, John H.
Y1  - 2021
N1  - 
T2  - Current Diagnosis & Treatment: Rheumatology, 4e
AB  - Sjögren  syndrome  (SjS)  is  a  systemic  autoimmune  disease  that  presents  with  sicca  symptomatology  of  mucosal  surfaces.The  main  sicca  features  (xerophthalmia  and  xerostomia)  are  determined  by  specific  ocular  tests  (corneal  stainings  and  Schirmer  test)  and  oral  investigations  (salivary  flow  measurement  and  parotid  scintigraphy).The  histologic  hallmark  is  a  focal  lymphocytic  infiltration  of  the  exocrine  glands,  determined  by  a  biopsy  of  the  minor  labial  salivary  glands.The  spectrum  of  the  disease  includes  systemic  features  (extraglandular  manifestations)  in  some  patients,  and  is  complicated  by  the  development  of  lymphoma  in  a  small  percentage  of  patients.Patients  with  SjS  can  be  characterized  by  a  broad  spectrum  of  laboratory  features  (cytopenias,  hypergammaglobulinemia,  and  high  erythrocyte  sedimentation  rate)  and  autoantibodies,  of  which  antinuclear  antibodies  are  the  most  frequently  detected,  anti-Ro/SS-A  the  most  specific,  and  cryoglobulins  and  hypocomplementemia  the  main  prognostic  markers.  
SN  - 
PB  - McGraw Hill
CY  - New York, NY
Y2  - 2024/04/19
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1180196959
ER  -