TY - CHAP M1 - Book, Section TI - Systemic Lupus Erythematosus A1 - Dall’Era, Maria A2 - Stone, John H. Y1 - 2021 N1 - T2 - Current Diagnosis & Treatment: Rheumatology, 4e AB - Predilection for females of childbearing age.Multisystem disease that has a tendency to remit and relapse.Photosensitive rash, polyarthritis, serositis, and fatigue are common flare manifestations.Renal disease, central nervous system involvement, and complications of antiphospholipid antibodies can cause major morbidity.Treatment-related morbidity, particularly from glucocorticoids, constitutes a major source of damage associated with having lupus.Presence of antinuclear antibodies.Certain autoantibodies (anti-dsDNA and anti-Sm) have great specificity for the diagnosis of systemic lupus erythematosus (SLE) but lack sensitivity.Hypocomplementemia may occur during flares. SN - PB - McGraw Hill CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=1180196547 ER -