TY - CHAP M1 - Book, Section TI - Production, Distribution, and Activation of Monocytes and Macrophages A1 - Douglas, Steven D. A1 - Douglas, Anne G. A2 - Kaushansky, Kenneth A2 - Prchal, Josef T. A2 - Burns, Linda J. A2 - Lichtman, Marshall A. A2 - Levi, Marcel A2 - Linch, David C. Y1 - 2021 N1 - T2 - Williams Hematology, 10e AB - SUMMARYMonocytes and macrophages play important roles in human biology, both as components of the hematopoietic system and within the stroma and tissue microenvironment, where they contribute trophic and clearance functions. They constitute a widely dispersed cellular system throughout the body, interacting with host cells and foreign invaders through their versatile biosynthetic and secretory responses, all designed to maintain physiologic homeostasis. Included within the “family” of monocyte and macrophages are specialized migratory or sessile phagocytes, present within the circulation and extravascular tissue compartment, which contribute to diverse pathologic processes directly and through their production of bioactive products. Monocytes and macrophages display much heterogeneity and plasticity. The origin, lifespan, and functions of the monocyte are the focus of this chapter, including their relevance to health and disease in humans, based on current understanding of their properties. The relationship of monocytes and macrophages to dendritic cells and monocyte-derived cells with a specialized immunologic role in T-lymphocyte activation are described. Together, macrophages and dendritic cells are major antigen-presenting cells, contributing to host defense, innate and acquired immunity, and inflammation, as well as noninfectious disease processes, both within and outside the lymphohematopoietic organs. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1178748585 ER -