TY - CHAP M1 - Book, Section TI - Fixed Drug Eruption A1 - Hardin, J. Matthew A2 - Knoop, Kevin J. A2 - Stack, Lawrence B. A2 - Storrow, Alan B. A2 - Thurman, R. Jason Y1 - 2021 N1 - T2 - The Atlas of Emergency Medicine, 5e AB - Fixed drug eruptions (FDEs) appear 3 to 14 days after 1st exposure. The lesions can appear anywhere, including mucous membranes, but are most common on the face, lips, hands, feet, and genitalia. Single or multiple annular, edematous, well-demarcated plaques are typical. A central vesicle, bulla, or erosion may occur. After stopping the offending medication, the lesion(s) fade over several days to weeks. Residual hyperpigmentation is common. Within 24 hours of reexposure to the culprit medication, the exact rash reappears. The most common offending medications are sulfonamides, NSAIDs, barbiturates, tetracyclines, and carbamazepine. SN - PB - McGraw-Hill CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1181043780 ER -