TY - CHAP M1 - Book, Section TI - Hand, Foot, And Mouth Syndrome A1 - Shah, Ashish A1 - Sobolewski, Brad A1 - Mittiga, Matthew R. A2 - Knoop, Kevin J. A2 - Stack, Lawrence B. A2 - Storrow, Alan B. A2 - Thurman, R. Jason Y1 - 2021 N1 - T2 - The Atlas of Emergency Medicine, 5e AB - Hand, foot, and mouth syndrome (HFMS) is a seasonal (summer-fall) viral infection caused most frequently by coxsackievirus A16, with other enterovirus serotypes implicated less frequently. Toddlers and school-aged children are affected most commonly, although adults may also be affected. It is characterized by a prodrome of fever, malaise, sore throat, and anorexia over 1 to 2 days, followed by the appearance of the characteristic enanthem in the posterior oropharynx and tonsillar pillars consisting of small, red macules evolving into small vesicles 1 to 3 mm in diameter that rapidly ulcerate. Oral manifestations are followed by a vesicular eruption characterized by 3- to 7-mm erythematous macules with a central gray vesicle on the hands and feet involving the palmar and plantar surfaces and interdigital surfaces. A nonvesicular rash may also be present on the buttocks, face, and legs. SN - PB - McGraw-Hill CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1181044389 ER -