TY - CHAP M1 - Book, Section TI - Immunodeficiency A1 - Levinson, Warren A1 - Chin-Hong, Peter A1 - Joyce, Elizabeth A. A1 - Nussbaum, Jesse A1 - Schwartz, Brian Y1 - 2020 N1 - T2 - Review of Medical Microbiology & Immunology: A Guide to Clinical Infectious Diseases, 16e AB - Immunodeficiency can occur in any of the four major components of the immune system: (1) B cells (antibody), (2) T cells, (3) complement, and (4) phagocytes. In a patient with a history of infections that are unusually frequent, unusually severe, or caused by unusual organisms, the pattern of these infections can indicate which component(s) of the immune system might be defective. Most immunodeficiencies are acquired, and these are frequently caused by immunosuppressive medications, transplantation, and/or diseases that suppress immunity. Although they are less common, congenital immunodeficiencies (Table 68–1) are important to understand because (1) the patterns of infections that are seen teach us how various immune components are supposed to function normally, and (2) recent technological advances have allowed us to better diagnose and treat these diseases, preventing the infectious complications. SN - PB - McGraw Hill CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1175827354 ER -