TY - CHAP M1 - Book, Section TI - ISOCYANATES A1 - Blanc, Paul D. A2 - Olson, Kent R. A2 - Anderson, Ilene B. A2 - Benowitz, Neal L. A2 - Blanc, Paul D. A2 - Clark, Richard F. A2 - Kearney, Thomas E. A2 - Kim-Katz, Susan Y. A2 - Wu, Alan H. B. Y1 - 2018 N1 - T2 - Poisoning & Drug Overdose, 7e AB - Toluene diisocyanate (TDI), methylene diisocyanate (MDI), hexamethylene diisocyanate (HDI), isophorone diisocyanate (IPDI), and related chemicals are industrial components in the polymerization of urethane coatings and insulation materials. Urethanes have widespread uses in sealants, coatings, finishes, glues, and even medical applications (eg, casts). Most two-part urethane products contain some amount of one of these chemicals, and lesser amounts contaminate one-part systems. Methyl isocyanate (the toxin released in the disaster in Bhopal, India) is a carbamate insecticide precursor; it is not used in urethanes, has actions different from those of the TDI group of chemicals, and is not discussed here (see Table IV–4). SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1174606175 ER -