TY - CHAP M1 - Book, Section TI - COLCHICINE A1 - Sutter, Mark A2 - Olson, Kent R. A2 - Anderson, Ilene B. A2 - Benowitz, Neal L. A2 - Blanc, Paul D. A2 - Clark, Richard F. A2 - Kearney, Thomas E. A2 - Kim-Katz, Susan Y. A2 - Wu, Alan H. B. Y1 - 2018 N1 - T2 - Poisoning & Drug Overdose, 7e AB - Colchicine is FDA approved for the treatment and prophylaxis of gout and familial Mediterranean fever. It is also used for acute and recurrent pericarditis and a variety of inflammatory conditions such as Behçet disease. It is available in tablet form, and it is also found in certain plants, such as Colchicum autumnale (autumn crocus or meadow saffron) and Gloriosa superba (glory lily). The injectable form of colchicine was banned in 2009 by the FDA due to serious toxicity. Its antimitotic mechanism of action is similar to that of some chemotherapeutic agents, and colchicine overdoses are extremely serious, with considerable mortality. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1174605665 ER -