TY - CHAP M1 - Book, Section TI - ANTIDEPRESSANTS, TRICYCLIC A1 - Benowitz, Neal L. A2 - Olson, Kent R. A2 - Anderson, Ilene B. A2 - Benowitz, Neal L. A2 - Blanc, Paul D. A2 - Clark, Richard F. A2 - Kearney, Thomas E. A2 - Kim-Katz, Susan Y. A2 - Wu, Alan H. B. Y1 - 2018 N1 - T2 - Poisoning & Drug Overdose, 7e AB - Tricyclic antidepressants taken in overdose by suicidal patients are a substantial cause of poisoning hospitalizations and deaths. Currently available tricyclic antidepressants are described in Table II–8. Amitriptyline also is marketed in combination with chlordiazepoxide (Limbitrol) or perphenazine (Etrafon or Triavil). Cyclobenzaprine (Flexeril), a centrally acting muscle relaxant, is structurally related to the tricyclic antidepressants but exhibits minimal cardiotoxic and variable CNS effects. Newer, noncyclic antidepressants are discussed on Antidepressants, General (Noncyclic) are discussed on Monoamine Oxidase Inhibitors. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=1174605046 ER -