TY - CHAP M1 - Book, Section TI - The Pathophysiology of Male Infertility A1 - Ghayda, Ramy Abou A1 - Kathrins, Martin A2 - Bhasin, Shalender A2 - O’Leary, Michael P. A2 - Basaria, Shehzad S. Y1 - 2021 N1 - T2 - Essentials of Men’s Health AB - The sperm is the smallest cell in the human body and likely one of the most extensively studied. The year 2018 saw the publication of the 100,000th scientific paper on this topic. Normal spermatogenesis is highly regulated and reproducible. However, this process, which results in the production of mature male gametes, is subject to congenital or acquired disturbances, often leading to infertility. A male factor is thought to be responsible as the sole or contributing factor in 50% of all couples with infertility. Almost 7% of all men are confronted with fertility problems.1 The pathophysiological factors leading to male-factor infertility are divided into pretesticular, testicular, and posttesticular. Despite all the technological advances and innovation in the diagnosis and evaluation of male infertility, idiopathic etiologies still represent 50% of overall infertility cases. SN - PB - McGraw Hill CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=1174515042 ER -