TY - CHAP M1 - Book, Section TI - Glomerular Diseases A1 - Jameson, J. Larry A1 - Fauci, Anthony S. A1 - Kasper, Dennis L. A1 - Hauser, Stephen L. A1 - Longo, Dan L. A1 - Loscalzo, Joseph Y1 - 2020 N1 - T2 - Harrison's Manual of Medicine, 20e AB - Historically called the “nephritic syndrome.” Characterized by development, over days, of azotemia, hypertension, edema, hematuria, proteinuria, and sometimes oliguria. Salt and water retention are due to reduced glomerular filtration rate (GFR) and may result in circulatory congestion. Red blood cell (RBC) casts on urinalysis confirm diagnosis. Proteinuria is usually <3 g/d. Most forms of acute GN are mediated by humoral immune mechanisms. Clinical course depends on underlying lesion (Table 145-1). SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/23 UR - accessmedicine.mhmedical.com/content.aspx?aid=1167067527 ER -