TY - CHAP M1 - Book, Section TI - Tubulointerstitial Diseases A1 - Dirkx, Tonja C. A1 - Woodell, Tyler A2 - Papadakis, Maxine A. A2 - McPhee, Stephen J. A2 - Rabow, Michael W. Y1 - 2020 N1 - T2 - Current Medical Diagnosis and Treatment 2020 AB - Tubulointerstitial disease may be acute or chronic. Acute disease is most commonly associated with medications, infectious agents, and systemic rheumatologic disorders. Interstitial edema, infiltration with polymorphonuclear neutrophils, and tubular cell necrosis can be seen. (See Acute Kidney Injury, above, and Table 22–9.) Chronic disease is associated with insults from an acute factor or progressive insults without any obvious acute cause. Interstitial fibrosis and tubular atrophy are present, with a mononuclear cell predominance. The chronic disorders are described below. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2022/05/24 UR - accessmedicine.mhmedical.com/content.aspx?aid=1166170945 ER -