TY - CHAP M1 - Book, Section TI - AIDS and Lentiviruses A1 - Riedel, Stefan A1 - Hobden, Jeffery A. A1 - Miller, Steve A1 - Morse, Stephen A. A1 - Mietzner, Timothy A. A1 - Detrick, Barbara A1 - Mitchell, Thomas G. A1 - Sakanari, Judy A. A1 - Hotez, Peter A1 - Mejia, Rojelio Y1 - 2019 N1 - T2 - Jawetz, Melnick, & Adelberg's Medical Microbiology, 28e AB - Human immunodeficiency virus (HIV) types, derived from primate lentiviruses, are the etiologic agents of Acquired Immune Deficiency Syndrome (AIDS). The illness was first described in 1981, and HIV-1 was isolated by the end of 1983. Since then, AIDS has become a worldwide epidemic, expanding in scope and magnitude as HIV infections have affected different populations and geographic regions. Millions are now infected worldwide; once infected, individuals remain infected for life. Within a decade, if left untreated, the vast majority of HIV-infected individuals develop fatal opportunistic infections as a result of HIV-induced deficiencies in the immune system. AIDS is one of the most important public health problems worldwide at the start of the 21st century. The development of highly active antiretroviral therapy (HAART) for chronic suppression of HIV replication and prevention of AIDS has been a major achievement in HIV medicine. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1163284258 ER -