TY - CHAP M1 - Book, Section TI - Chancroid A1 - Lautenschlager, Stephan A1 - Brockmeyer, Norbert H. A2 - Kang, Sewon A2 - Amagai, Masayuki A2 - Bruckner, Anna L. A2 - Enk, Alexander H. A2 - Margolis, David J. A2 - McMichael, Amy J. A2 - Orringer, Jeffrey S. Y1 - 2019 N1 - T2 - Fitzpatrick's Dermatology, 9e AB - AT-A-GLANCEChancroid is a sexually transmitted acute ulcerative disease usually localized at the anogenital area and often associated with inguinal adenitis or bubo.Haemophilus ducreyi—a Gram-negative, facultative anaerobic coccobacillus—is the causative agent.Chancroid is disappearing even from most countries where H. ducreyi was previously epidemic, with the exception of North India and Malawi. Nevertheless, recent sporadic case reports from Western Europe have been described, often initially misdiagnosed as genital herpes.Painful, soft ulcers with ragged undermined margins develop 1 to 2 weeks after inoculation (usually prepuce and frenulum in men and vulva, cervix, and perianal areas in women).H. ducreyi facilitates the transmission of HIV.In contrast to a sustained reduction in the proportion of genital ulcer disease caused by H. ducreyi, the bacterium is increasingly found in the South Pacific region and in Africa as a common cause of nongenital cutaneous ulcers especially in children.Laboratory culture of H. ducreyi is problematic, but greater sensitivity can be expected by nucleic acid amplification methods, which are not routinely available.Azithromycin and ceftriaxone are recommended as single-dose treatment, enhancing compliance. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1161341463 ER -