TY - CHAP M1 - Book, Section TI - Cutaneous Changes in Arterial, Venous, and Lymphatic Dysfunction A1 - Newman, Sabrina A. A2 - Kang, Sewon A2 - Amagai, Masayuki A2 - Bruckner, Anna L. A2 - Enk, Alexander H. A2 - Margolis, David J. A2 - McMichael, Amy J. A2 - Orringer, Jeffrey S. Y1 - 2019 N1 - T2 - Fitzpatrick's Dermatology, 9e AB - AT-A-GLANCEMost commonly caused by atherosclerosis of the vessels supplying the lower extremity.Affects 15% of the U.S. adult population older than age 65 years.Stenosis or obstruction of the large arteries to the lower extremities leading to supply–demand mismatch, initially with exertion, but may progress to occur at rest.Intermittent claudication with exertional muscle pain or fatigue, critical limb ischemia with rest pain or tissue compromise, and acute limb ischemia.Cutaneous findings from hypoperfusion range from dry skin, hair loss, and malformed toenails to ulceration and gangrene. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/16 UR - accessmedicine.mhmedical.com/content.aspx?aid=1161351033 ER -