TY - CHAP M1 - Book, Section TI - Polymorphic Light Eruption A1 - Gruber-Wackernagel, Alexandra A1 - Wolf, Peter A2 - Kang, Sewon A2 - Amagai, Masayuki A2 - Bruckner, Anna L. A2 - Enk, Alexander H. A2 - Margolis, David J. A2 - McMichael, Amy J. A2 - Orringer, Jeffrey S. Y1 - 2019 N1 - T2 - Fitzpatrick's Dermatology, 9e AB - AT-A-GLANCEPolymorphic light eruption is the most common photodermatosis with a female preponderance typically presenting in the spring.Clinical presentation: A pruritic, erythematous, symmetrically distributed, eruption of variable interindividual morphology (in most cases papular) on sun-exposed skin areas, within hours to days of exposure, with full resolution in several days.Histopathology: Epidermal spongiosis with a superficial and deep dermal, perivascular, mixed-cell infiltrate and papillary dermal edema.Etiology and Pathogenesis: A resistance to ultraviolet (UV)-induced immune suppression with subsequent delayed-type hypersensitivity reaction against UV-induced antigen(s).Prevention and Therapy: Responds to broad-spectrum sunscreen use, oral or topical steroids, and prophylactic low-dose immunosuppressive phototherapy. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1161327066 ER -