TY - CHAP M1 - Book, Section TI - The Immunological Structure of the Skin A1 - Stingl, Georg A1 - Brüggen, Marie-Charlotte A2 - Kang, Sewon A2 - Amagai, Masayuki A2 - Bruckner, Anna L. A2 - Enk, Alexander H. A2 - Margolis, David J. A2 - McMichael, Amy J. A2 - Orringer, Jeffrey S. Y1 - 2019 N1 - T2 - Fitzpatrick's Dermatology, 9e AB - At-A-GlanceSkin is a “Grenzorgan” equipped with the capacity to mount and execute immune responses.The cutaneous immune system disposes of an innate and adaptive arm to exert these functions.Molecular constituents of the cutaneous immune system include pattern recognition receptors and effector molecules.Tissue homeostasis requires the prevention of exaggerated responses to innocuous substances and the occurrence of host-defense reactions at a subclinical level, ie, in the absence of inflammation.Under pathological conditions, danger signals or other disease-eliciting/-promoting factors in the skin elicit a coordinated (host defense) reaction of its cellular and molecular elements. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/11/03 UR - accessmedicine.mhmedical.com/content.aspx?aid=1161321000 ER -