TY  - CHAP
M1  - Book, Section
TI  - Disorders of Purine and Pyrimidine Metabolism
A1  - Mecchella, John N.
A1  - Burns, Christopher M.
A2  - Jameson, J. Larry
A2  - Fauci, Anthony S.
A2  - Kasper, Dennis L.
A2  - Hauser, Stephen L.
A2  - Longo, Dan L.
A2  - Loscalzo, Joseph
Y1  - 2018
N1  - 
T2  - Harrison's Principles of Internal Medicine, 20e
AB  - Purines  (adenine  and  guanine)  and  pyrimidines  (cytosine,  thymine,  uracil)  serve  fundamental  roles  in  the  replication  of  genetic  material,  gene  transcription,  protein  synthesis,  and  cellular  metabolism.  Disorders  that  involve  abnormalities  of  nucleotide  metabolism  range  from  relatively  common  diseases  such  as  hyperuricemia  and  gout,  in  which  there  is  increased  production  or  impaired  excretion  of  a  metabolic  end  product  of  purine  metabolism  (uric  acid),  to  rare  enzyme  deficiencies  that  affect  purine  and  pyrimidine  synthesis  or  degradation.  Understanding  these  biochemical  pathways  has  led,  in  some  instances,  to  the  development  of  specific  forms  of  treatment,  such  as  the  use  of  allopurinol  and  febuxostat  to  reduce  uric  acid  production.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/20
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1156564320
ER  -