TY - CHAP M1 - Book, Section TI - Tumors of the Liver and Biliary Tree A1 - Llovet, Josep M. A2 - Jameson, J. Larry A2 - Fauci, Anthony S. A2 - Kasper, Dennis L. A2 - Hauser, Stephen L. A2 - Longo, Dan L. A2 - Loscalzo, Joseph Y1 - 2018 N1 - T2 - Harrison's Principles of Internal Medicine, 20e AB - The burden of cancer is increasing worldwide. Lung, breast, and colorectal cancers are the most commonly diagnosed while lung and liver cancers are the most common causes of cancer death. Liver cancer is the sixth most common cancer worldwide, the second leading cause of cancer-related deaths and one of the few neoplasms whose incidence and mortality rates have been steadily increasing. Liver cancer comprises a heterogeneous group of malignant tumors with different histologic features and unfavorable prognosis that range from hepatocellular carcinoma (HCC; 85–90% cases), intrahepatic cholangiocarcinoma (iCCA; 10%), and other malignancies accounting for <1% of tumors, such as fibrolamellar HCC, mixed HCC-iCCA, epithelioid hemangiothelioma, and the pediatric cancer hepatoblastoma. The burden of liver cancer is increasing globally in almost all countries, and it is estimated to reach one million cases by 2030. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/16 UR - accessmedicine.mhmedical.com/content.aspx?aid=1156514128 ER -