TY - CHAP M1 - Book, Section TI - Nucleotides A1 - Rodwell, Victor W. A2 - Rodwell, Victor W. A2 - Bender, David A. A2 - Botham, Kathleen M. A2 - Kennelly, Peter J. A2 - Weil, P. Anthony Y1 - 2018 N1 - T2 - Harper's Illustrated Biochemistry, 31e AB - OBJECTIVESAfter studying this chapter, you should be able to:Write structural formulas to represent the amino- and oxo-tautomers of a purine and of a pyrimidine and state which tautomer predominates under physiologic conditions.Reproduce the structural formulas for the principal nucleotides present in DNA and in RNA and the less common nucleotides 5-methylcytosine, 5-hydroxymethylcytosine, and pseudouridine (ψ).Represent D-ribose or 2-deoxy-D-ribose linked as either a syn or an anti conformer to a purine, name the bond between the sugar and the base, and indicate which conformer predominates under most physiologic conditions.Number the C and N atoms of a pyrimidine ribonucleoside and of a purine deoxyribonucleoside, including using a primed numeral for C atoms of the sugars.Compare the phosphoryl group transfer potential of each phosphoryl group of a nucleoside triphosphate.Outline the physiologic roles of the cyclic phosphodiesters cAMP and cGMP.Appreciate that polynucleotides are directional macromolecules composed of mononucleotides linked by 3′ → 5′-phosphodiester bonds.Be familiar with the abbreviated representations of polynucleotide structures such as pTpGpT or TGCATCA, for which the 5′-end is always shown at the left and all phosphodiester bonds are 3′ → 5′.For specific synthetic analogs of purine and pyrimidine bases and their derivatives that have served as anticancer drugs, indicate in what ways these compounds inhibit metabolism. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1160190500 ER -