TY - CHAP M1 - Book, Section TI - Acute Kidney Injury A1 - Waikar, Sushrut S. A1 - Bonventre, Joseph V. A2 - Jameson, J. Larry A2 - Fauci, Anthony S. A2 - Kasper, Dennis L. A2 - Hauser, Stephen L. A2 - Longo, Dan L. A2 - Loscalzo, Joseph Y1 - 2018 N1 - T2 - Harrison's Principles of Internal Medicine, 20e AB - Acute kidney injury (AKI) is defined by the impairment of kidney filtration and excretory function over days to weeks, resulting in the retention of nitrogenous and other waste products normally cleared by the kidneys. AKI is not a single disease but, rather, a designation for a heterogeneous group of conditions that share common diagnostic features: specifically, an increase in serum creatinine (SCr) concentration often associated with a reduction in urine volume. It is important to recognize that AKI is a clinical diagnosis and not a structural one. A patient may have AKI with or without injury to the kidney parenchyma. AKI can range in severity from asymptomatic and transient changes in laboratory parameters of glomerular filtration rate (GFR), to overwhelming and rapidly fatal derangements in effective circulating volume regulation and electrolyte and acid-base composition of the plasma. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/19 UR - accessmedicine.mhmedical.com/content.aspx?aid=1157019219 ER -