TY - CHAP M1 - Book, Section TI - Chronic Tubulointerstitial Nephritis A1 - Dorsainvil, Dominique A1 - Luciano, Randy L. A2 - Lerma, Edgar V. A2 - Rosner, Mitchell H. A2 - Perazella, Mark A. Y1 - 2017 N1 - T2 - CURRENT Diagnosis & Treatment: Nephrology & Hypertension, 2e AB - Chronic tubulointerstitial nephritis (CTIN) is an inflammatory process that involves the peritubular space or interstitium of the kidneys resulting in interstitial scarring with fibrosis, a lymphomonocytic infiltrate, tubular dilation, and atrophy. These forms of injury are very similar regardless of the inciting cause. Usually asymptomatic, it presents as a slowly progressive impairment in renal function leading to chronic kidney disease (CKD). Any structural damage, either glomerular, tubular, or a direct injury to the interstitium from an acute nephritis that has not appropriately resolved can amount to CTIN. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/11/03 UR - accessmedicine.mhmedical.com/content.aspx?aid=1149115080 ER -