TY - CHAP M1 - Book, Section TI - Plasma Cell Dyscrasias A1 - Leung, Nelson A1 - Nasr, Samih H. A2 - Lerma, Edgar V. A2 - Rosner, Mitchell H. A2 - Perazella, Mark A. Y1 - 2017 N1 - T2 - CURRENT Diagnosis & Treatment: Nephrology & Hypertension, 2e AB - ESSENTIALS OF DIAGNOSISImmune deposits are considered monotypic if they display light chain restriction.Heavy chain restriction without light chain restriction is not considered monotypic as several polyclonal diseases can have heavy chain isotype restriction.C3 glomerulonephritis and thrombotic microangiopathy do not have immunoglobulin deposits but can be due to monoclonal gammopathy.Immunofluorescence (IF) on paraffin tissue after protease digestion should be performed on all cases of C3 glomerulonephritis with monoclonal gammopathy to look for masked immunoglobulin deposits.All amyloidosis cases should undergo tissue typing prior to initiation of chemotherapy. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=1149114485 ER -