TY  - CHAP
M1  - Book, Section
TI  - NSAIDs and the Kidney: Acute Kidney Injury
A1  - Perazella, Mark A.
A2  - Lerma, Edgar V.
A2  - Rosner, Mitchell H.
A2  - Perazella, Mark A.
Y1  - 2017
N1  - 
T2  - CURRENT Diagnosis & Treatment: Nephrology & Hypertension, 2e
AB  - ESSENTIALS  OF  DIAGNOSISNonsteroidal  anti-inflammatory  drug  (NSAID)-associated  acute  kidney  injury  (AKI)  develops  predominantly  in  patients  with  underlying  risk  factors.Clinical  presentations  can  be  asymptomatic  or  associated  with  uremic  symptoms,  edema  (pulmonary  and  peripheral),  hypertension,  or  electrolyte  and  acid–base  disturbances.Elevated  blood  urea  nitrogen  (BUN)  and  serum  creatinine  (Cr)  concentrations  are  present.An  elevated  BUN/Cr  ratio  (>20)  is  often  noted.Hyponatremia  (serum  [Na+]  5.5  mEq/L),  and  nonanion  gap  metabolic  acidosis  (serum  [HCO3–]  <20  mEq/L)  are  common.Urine  [Na+]  <10–20  mEq/L  and  FENa+  <1.0%  characterize  NSAID-associated  AKI.AKI  is  generally  reversible  with  discontinuation  of  NSAIDs  and  treatment  of  concurrent  disease  processes.Severe  AKI  from  NSAIDs  may  require  dialysis.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/24
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1149112756
ER  -