TY - CHAP M1 - Book, Section TI - BIOLOGY OF THE VESSEL WALL A1 - Johnston-Cox, Hillary A1 - Fuster, Valentin A1 - Kovacic, Jason C. A2 - Fuster, Valentin A2 - Harrington, Robert A. A2 - Narula, Jagat A2 - Eapen, Zubin J. Y1 - 2017 N1 - T2 - Hurst's The Heart, 14e AB - The pathogenesis of common cardiovascular diseases, including atherosclerosis and hypertension, involves diverse and complex pathways. Significant advances in our understanding of the underlying pathobiologies at a molecular and cellular level are increasingly leading to the development of new therapeutic strategies targeted at primary etiologies rather than secondary manifestations of vascular disease. Thus, it is essential for both inquisitive scientists and clinicians who are taking care of patients with cardiovascular disease to understand the normal physiology, signaling pathways, and function of the different cell types that constitute the layers of the vascular wall, in addition to the complex interactions between the vasculature, the heart and the entire human organism (Fig. 7–1). This chapter will provide relevant basic knowledge about the underlying physiology and function of each component of the vasculature and how disease conditions alter this carefully regulated system. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1161723659 ER -