TY - CHAP M1 - Book, Section TI - The Eicosanoids: Prostaglandins, Thromboxanes, Leukotrienes, & Related Compounds A1 - Hwa, John A1 - Martin, Kathleen A2 - Katzung, Bertram G. Y1 - 2017 N1 - T2 - Basic & Clinical Pharmacology, 14e AB - CASE STUDYA 40-year-old woman presented to her doctor with a 6-month history of increasing shortness of breath. This was associated with poor appetite and ankle swelling. On physical examination, she had elevated jugular venous distention, a soft tricuspid regurgitation murmur, clear lungs, and mild peripheral edema. An echocardiogram revealed tricuspid regurgitation, severely elevated pulmonary pressures, and right ventricular enlargement. Cardiac catheterization confirmed the severely elevated pulmonary pressures. She was commenced on appropriate therapies. Which of the eicosanoid agonists have been demonstrated to reduce both morbidity and mortality in patients with such a diagnosis? What are the modes of action? SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1148435429 ER -