TY  - CHAP
M1  - Book, Section
TI  - Population Genetics and Genetic Diversity
A1  - Schaefer, G. Bradley
A1  - Thompson, Jr., James N.
Y1  - 2017
N1  - 
T2  - Medical Genetics: An Integrated Approach
AB  - A  question  about  inheritance  usually  focuses  on  individuals  or  families.  That  is  not  surprising.  Individuals  are  the  object  of  medical  concern.  Families  give  us  information  about  the  genes  they  have  inherited—and  which  relatives  might,  too.  But  we  have  already  seen  how  we  can  learn  important  information  by  expanding  our  perspective  to  groups  of  families  through  pedigrees.  Pedigree  analysis  tells  us  things  about  transmission  that  an  individual  family  with  a  small  number  of  children  might  not.  New  information  surfaces.  But  even  single  families  do  not  explain  many  important  factors.  For  example,  we  cannot  quantify  the  amount  of  a  trait's  penetrance  from  just  a  single  family  or  even  a  pedigree  of  several  families.  We  may  be  able  to  find  one,  or  even  a  few,  examples  of  incomplete  penetrance.  But  that  does  not  tell  us  how  often  that  event  will  happen  in  the  population  as  a  whole.  Yet,  it  is  on  that  population  frequency  that  individual  predictions  depend.  We  must  look  at  many  families  in  which  the  trait  is  segregating.  We  must  use  "population  thinking."  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/25
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1147723570
ER  -