TY - CHAP M1 - Book, Section TI - Blood Coagulation and Anticoagulant, Fibrinolytic, and Antiplatelet Drugs A1 - Hogg, Kerstin A1 - Weitz, Jeffrey I. A2 - Brunton, Laurence L. A2 - Hilal-Dandan, Randa A2 - Knollmann, Björn C. Y1 - 2017 N1 - T2 - Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 13e AB - Blood must remain fluid within the vasculature and yet clot quickly when exposed to subendothelial surfaces at sites of vascular injury. Under normal circumstances, a delicate balance between coagulation and fibrinolysis prevents both thrombosis and hemorrhage. Alteration of this balance in favor of coagulation results in thrombosis. Thrombi, composed of platelet aggregates, fibrin, and trapped red blood cells, can form in arteries or veins. Antithrombotic drugs used to treat thrombosis include antiplatelet drugs, which inhibit platelet activation or aggregation; anticoagulants, which attenuate fibrin formation; and fibrinolytic agents, which degrade fibrin. All antithrombotic drugs increase the risk of bleeding. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/11/07 UR - accessmedicine.mhmedical.com/content.aspx?aid=1162539182 ER -