TY  - CHAP
M1  - Book, Section
TI  - Bedside Statistical Tools
A1  - Doucette, John T.
A1  - Krasnica, Steven
A2  - Oropello, John M.
A2  - Pastores, Stephen M.
A2  - Kvetan, Vladimir
Y1  - 1
N1  - 
T2  - Critical Care
AB  - A  primary  goal  for  clinicians  is  to  evaluate  the  benefits  and  harms  from  the  treatment  options  before  them.  Primum  non  nocere  is  a  basic  principle  of  ethical  practice.  “Evidence-based  medicine  is  the  conscientious,  explicit,  and  judicious  use  of  the  current  best  evidence  in  making  decisions  about  the  care  of  individual  patients.  The  practice  of  evidence-based  medicine  means  integrating  the  individual  clinical  expertise  with  the  best  available  external  evidence  from  systematic  review.”1  Since  the  1990s,  evidence-based  medicine  (EBM)  has  been  gaining  a  strong  foothold  in  most  disciplines  of  medicine.  In  order  to  practice  EBM,  however,  it  is  paramount  that  clinicians  are  capable  of  assessing  and  synthesizing  medical  literature.  Effective  physicians  comprehend  the  balance  between  personal  clinical  experience  and  evidence  from  appropriately  conducted  research.  Clinicians  need  to  proficiently  assess  the  quality  of  published  studies  with  respect  to  design,  conduct,  and  analysis,  and  then  to  determine  the  relevance  and  external  validity  to  their  specific  patient.  Not  all  evidence  is  equal,  nor  does  it  offer  definite  clinical  plans  of  care.  One  needs  to  understand  the  basic  threats  to  the  validity  of  studies,  namely  bias,  confounding,  and  chance.  The  randomized  controlled  trial  (RCT)  and  meta-analysis  are  regarded  as  the  gold  standard  of  EBM.  However,  RCTs  are  difficult  to  perform  in  critical  care  medicine.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/16
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1136420352
ER  -