TY - CHAP M1 - Book, Section TI - Controversies: ScvO2 Versus Lactate Clearance to Guide Resuscitation in Septic Shock? A1 - Bakker, Jan A2 - Oropello, John M. A2 - Pastores, Stephen M. A2 - Kvetan, Vladimir Y1 - 1 N1 - T2 - Critical Care AB - Septic shock has been defined as a state in which hypotension persists despite adequate fluid resuscitation or the presence of a lactate level more than 4 mmol/L (so-called sepsis-induced tissue hypoperfusion) in patients with confirmed or suspected infection.1 In these conditions, the Surviving Sepsis Campaign Guidelines suggest to restore mean arterial pressure (MAP) more than 65 mm Hg and normalize lactate levels and central or mixed venous hemoglobin saturation (ScvO2/SvO2).1 Basically this reflects restoring perfusion pressure, improving tissue perfusion and restoring the balance between oxygen delivery and oxygen demand. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=1136418403 ER -