TY - CHAP M1 - Book, Section TI - Renal Transplantation A1 - Kasper, Dennis L. A1 - Fauci, Anthony S. A1 - Hauser, Stephen L. A1 - Longo, Dan L. A1 - Jameson, J. Larry A1 - Loscalzo, Joseph Y1 - 2016 N1 - T2 - Harrison's Manual of Medicine, 19e AB - With the advent of more potent and well-tolerated immunosuppressive regimens and further improvements in short-term graft survival, renal transplantation remains the treatment of choice for most pts with end-stage renal disease. Results are best with living-related transplantation, in part because of optimized tissue matching and in part because waiting time and ischemic time can be minimized; ideally, these pts are transplanted prior to the onset of symptomatic uremia or indications for dialysis. Transplant centers now also perform living-unrelated donor (e.g., spousal) transplants, often in “chains” involving multiple donors to optimize tissue matching. Graft survival in these cases is far superior to that observed with deceased donor transplants, although less favorable than with living-related transplants. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1128786633 ER -