TY - CHAP M1 - Book, Section TI - BCL-2 and ALK-1 Immunostains A1 - MA, Lichtman A1 - MS, Shafer A1 - RE, Felgar A1 - N, Wang Y1 - 2017 N1 - T2 - Lichtman's Atlas of Hematology 2016 AB - Graphic Jump LocationView Full Size||Download Slide (.ppt)X.E.001BCL-2 immunostain in follicular lymphoma. These images illustrate the typical staining of (A) neoplastic follicles in follicular lymphoma as compared to (B) benign, reactive germinal centers. Note that in follicular lymphoma neoplastic centrocytes equivalent to neoplastic germinal center cells overexpress the anti-apoptotic protein BCL-2 (arrows), whereas in reactive germinal center, no appreciable staining is noted (arrow), but mantle zone cells surrounding the germinal center (asterisk) are positive. In follicular lymphoma, the overexpression of BCL-2 can be attributed in about 80% to 85% of cases to a translocation involving the immunoglobulin heavy chain locus on chromosome 14q32 and the BCL-2 gene locus on chromosome 18q21, resulting in a constitutive overexpression of this protein. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/08 UR - accessmedicine.mhmedical.com/content.aspx?aid=1138038899 ER -