TY - CHAP M1 - Book, Section TI - Antimicrobials A1 - Rella, Joseph G. A1 - Carter, Wallace A. A2 - Tintinalli, Judith E. A2 - Stapczynski, J. Stephan A2 - Ma, O. John A2 - Yealy, Donald M. A2 - Meckler, Garth D. A2 - Cline, David M. Y1 - 2016 N1 - T2 - Tintinalli’s Emergency Medicine: A Comprehensive Study Guide, 8e AB - Adverse effects associated with antimicrobials occur primarily in three circumstances: side effects with therapeutic dosing, acute toxicity resulting from excessive dosing, and subacute to chronic effects from sustained therapeutic use. Side effects can be immunologic (allergic) or nonimmunologic (pharmacologic or idiosyncratic) in nature. Antibiotics cause more reported allergic reactions than other drugs, possibly due to their high frequency of use that is often in a repeated and interrupted fashion. Sometimes a diluent or other chemical constituent in the formulation of a drug causes the adverse effect. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1121513447 ER -