TY - CHAP M1 - Book, Section TI - Mast Cell Disorders A1 - Hamilton, Matthew J. A1 - Castells, Mariana A1 - Greenberger, Norton J. A2 - Greenberger, Norton J. A2 - Blumberg, Richard S. A2 - Burakoff, Robert Y1 - 2016 N1 - T2 - CURRENT Diagnosis & Treatment: Gastroenterology, Hepatology, & Endoscopy, 3e AB - ESSENTIALS OF DIAGNOSIS FOR MAST CELL ACTIVATION SYNDROMESigns and symptoms of mast cell activation that involve at least two organ systems and may include abdominal pain, diarrhea, flushing, headache, and concentration difficulties.No other medical disorder better explains these signs and symptoms.Objective evidence of mast cell activation while symptomatic including elevated levels of tryptase on a blood test, and/or elevated levels of mast cell metabolites including histamine and/or prostaglandin in a 24-hour urine specimen.Reduced symptoms with medications that block mast cell mediators such as antihistamines, cromolyn, and leukotriene antagonists. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/19 UR - accessmedicine.mhmedical.com/content.aspx?aid=1119988363 ER -