TY - CHAP M1 - Book, Section TI - Genetic and Molecular Changes in Lung Cancer: Prospects for a Personalized Pharmacological Approach to Treatment A1 - Li, Howard A1 - Kern, Jeffrey A. A2 - Grippi, Michael A. A2 - Elias, Jack A. A2 - Fishman, Jay A. A2 - Kotloff, Robert M. A2 - Pack, Allan I. A2 - Senior, Robert M. A2 - Siegel, Mark D. PY - 2015 T2 - Fishman's Pulmonary Diseases and Disorders, 5e AB - Lung cancer is the most common cause of cancer-related death in men and women worldwide, responsible for over 1 million deaths annually.1 Each year, more people die of lung cancer than of the next three leading causes of cancer death combined: breast, colon, and prostate cancer. Despite advances in surgical techniques and combined therapies, lung cancer remains a disease with a dismal prognosis. Although 1-year survival has improved over the past few decades, overall 5-year survival has remained relatively unchanged at 12% to 16% over the past 30 years.2 These data underscore the need to develop new diagnostic modalities and therapeutic approaches to target lung cancer. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/18 UR - accessmedicine.mhmedical.com/content.aspx?aid=1122366977 ER -