TY - CHAP M1 - Book, Section TI - Sleep Apnea Syndromes: Central and Obstructive A1 - Pien, Grace W. A1 - Rosen, Ilene M. A1 - Fields, Barry G. A2 - Grippi, Michael A. A2 - Elias, Jack A. A2 - Fishman, Jay A. A2 - Kotloff, Robert M. A2 - Pack, Allan I. A2 - Senior, Robert M. A2 - Siegel, Mark D. PY - 2015 T2 - Fishman's Pulmonary Diseases and Disorders, 5e AB - Sleep-disordered breathing (SDB) is an extremely common medical disorder associated with important morbidity. Recognition of its relevance in medicine is relatively recent, although clinical reports of SDB were first made in the 19th century.1 Likely influenced by such observations, descriptions of an entity constituting obesity and extreme somnolence were highlighted in the character narratives of the “fat boy” in Charles Dickens’ series, Posthumous Papers of the Pickwick Club, first published in 1837.2 Dickens described Joe, the fat boy, as a loud snorer who was obese and excessively somnolent—the classical description of Pickwickian syndrome. Sir William Osler in 1918 was credited with first linking the relationship between obesity and Pickwickian syndrome.3 In the mid-20th century, further work led to the association of Pickwickian syndrome with alveolar hypoventilation by Burwell et al. in 1956, and periodic cessation of respiration by Drachman and Gumnit in 1962.4,5 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/18 UR - accessmedicine.mhmedical.com/content.aspx?aid=1122366079 ER -